In Coimbra, Portugal, a lab is reprogramming glial cells into neurons. In Cambridge, a similar team researches how to rewrite the brain’s immune system and improve it’s response to damage. A research lab in Lisbon is mapping how inflammation outside the brain accelerates destruction inside it.
They work outside the spotlight while some of us silently hope for them to see a breakthrough. Because they can reshape the future of everyone living with Multiple Sclerosis, Alzheimer’s, Parkinson’s and other neurodegenerative diseases.
And they don’t know about each other. They publish in different journals and go to different conferences. Their silent fans aren’t even sure they exist.
This is the fragmentation problem. Our disconnection and cocooning into siloed groups is keeping us from sharing insights and bringing research into clinical practice faster.
And biology doesn’t work in silos. Remyelination matters to MS and to Alzheimer’s. Neuroinflammation matters to Parkinson’s and to stroke recovery. Cell reprogramming matters to all of them.
Today, we launch Brain-Regeneration.com — an open observatory and a bridge meant to bring us all together in one place.
What researchers and patients will find here
Brain-Regeneration.com tracks published research and clinical trials across the full landscape of central nervous system regeneration. Remyelination, neuroinflammation, stem-cell therapies, cell reprogramming — all updated within hours of publication, all searchable, all free.
The platform is powered by GregoryAI, an open-source software that harvests scientific literature and uses machine learning to surface the papers that matter most. It does not replace the expertise of researchers — it makes their work visible to the people who need it.
Already proven at scale
Brain-Regeneration.com builds on Gregory-MS.com, a platform running since 2021 that indexed over 42,000 articles, tracks 48 drugs and therapies, and delivers weekly alerts to researchers and patients. The AI models have flagged more than 4,400 papers as relevant for multiple sclerosis alone.
Gregory-MS started because a patient wanted to find the most recent research for his condition. Brain-Regeneration.com exists because the answer turned out to be bigger than one disease.
Guided by the researchers doing the work
Three scientific teams act as scientific curators of this project, defining the research areas, search queries, and curation criteria that shape the observatory.
REGENERAR, led by Prof. Lino Ferreira at the University of Coimbra, works on cell reprogramming — using epigenetic editing and non-viral delivery to turn the brain’s existing cells into functioning neurons.
LPJ Lab, led by Prof. Luca Peruzzotti-Jametti, investigates how cell metabolism shapes brain-immune interactions, opening new therapeutic paths for MS and other CNS disorders.
The CNS, Blood and Peripheral Inflammation Lab, iMed.ULisboa, led by Prof. Adelaide Fernandes, studies how inflammation drives the emergence and progression of neurodevelopmental and neurodegenerative disorders.
Their involvement means the observatory reflects real scientific priorities — not keyword algorithms, not editorial bias, not what generates clicks.
Open, transparent, and built for everyone
The software is open-source. The data is accessible through an open API. The project is managed by the Human-Singularity Network, a Portuguese non-profit, and funded entirely by donations. No paywalls. No institutional gatekeeping.
Join us
Subscribe to receive alerts when relevant research or clinical trials are published in your area of interest.
Share this with anyone — patients, caregivers, researchers, clinicians — who deserves to know what science is doing right now to repair the brain.
If you lead a research group working on brain regeneration and want to shape what the observatory covers, reach out. We are looking for Scientific Curators to expand into additional research areas.
Hope is difficult to find, and sometimes, we have to create it.
